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KMID : 0438219740110021141
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Korea University Medical Journal
1974 Volume.11 No. 2 p.1141 ~ p.1148
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Influences on the RN-ase Activity on Mice Subjected to Acute Starvation and Acute Stress
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Abstract
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This study was undertaken to investigate changes in serum RN-ase activities of mice subjected to acute starvation and acute stress, and to evaluate correlation between those changes and RN-ase inhibitor.
Experimental mice were devided into three groups, the first group subjected to acute starvation, was not fed except water, the second group subjected to acute stress, was given intraperitoneally 6mg celite per 100gm of body weight. The third group was offered to observe the effect of inactivation of RN-ase inhibitor by adding Pb in the incubation mixture.
For the measurement of serum RN-ase activity purified yeast RNA wes used as substrate, and mononucleotide was photometrically determined at 260nm
Following results are obtained;
1. Mice subjected to acute starvation showed rapid decrease in the serum RN-ase activity without recovery to normal level until death occured.
2. Mice subjected to acute starvation showed significant correlation between decrease of serum RN-ase activity and that of body weight.
3. Mice subjected to acute stress induced by peritoneal injection of celite showed rapid decrease of the serum RN-ase activity.
4. When RN-ase inhibitor was inactivated by adding Pb in the incubation mixture, serum RN-ase activity restored appraximately to normal level.
This fact suggests-that RN-ase inhibitor circulates in the blood during stress.
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KEYWORD
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